Also known as Oncogenic osteomalacia, oncogenic hypophosphatemic osteomalacia
What is it?
Tumor-induced osteomalacia (TIO) is a rare disease caused by tumors.
What Causes It?
TIO is characterized by a slow-growing tumor or multiple tumors that produce excess amounts of the protein FGF23, and subsequently causes weak bones.
What Are Some Common Symptoms?1
- Muscle weakness
- Fatigue
- Bone pain
- Fractures
How Many People Have It?
Approximately 500 to 1,000 people in the U.S. are living with TIO.
Download our resource guide for information on TIO, including how to manage symptoms, appointments, mental health, and lifestyle modifications.
Oncogenic osteomalacia. National Institutes of Health: Genetic and Rare Diseases Information Center Website. https://rarediseases.info.nih.gov/diseases/9652/oncogenic-osteomalacia. Updated October 19, 2017. Accessed October 31, 2021.
Intended for U.S. audiences only
Participate in TIO Research
To talk to someone and get more information about Ultragenyx clinical trials and research, email [email protected].
We aren’t currently recruiting for research in TIO, but there are other ways to connect and contribute. We’d love to hear your experience. If you would consider sharing your story with us, please email [email protected].
Read more about drug development here and engaging with other organizations such as the U.S. FDA here.
Research plays a critical part in advancing science and treatments. Volunteers who participate in this research are essential. Future therapies would not be possible without them. Participating in clinical trials, interviews, observational studies, and disease monitoring programs help to drive research, treatment development, and disease education. It is also a way to advocate for yourself and your community.
Upcoming Community Events
Participate in Events Near YouTIO Patient Advocacy Groups
If you are aware of any tumor-induced osteomalacia (TIO) advocacy groups, please contact [email protected].
Rare Experiences
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Ann
Tumor-induced Osteomalacia (TIO)“It’s okay to say, ‘I’m having a really hard time,’ but within that to say, ‘Are there little things I could do to start to make it better?’”
Dan
Tumor-induced Osteomalacia (TIO)“At 50 years old, I was a healthy, strong workaholic until everything changed.”
