What is it?

Glut 1 DS is rare, genetic disorder that prevents enough glucose (sugar) from getting to the brain, leaving the brain starving for energy.

What causes it?

People with Glut 1 DS have a mutation in a gene that controls the Glut1 transporter, which is the “vehicle” in the body that moves sugar into the brain. The genetic mutation causes the Glut 1 transporter to work improperly.

What are some of the common symptoms?

  • Seizures
  • Delay in speaking
  • Movement disorders
  • Learning difficulties

How many people have it?

Between 3,000 and 7,000 people in the U.S. have Glut1 DS.

Common names for Glut1 DS1

  • De Vivo disease
  • Encephalopathy due to GLUT1 deficiency
  • G1D
  • Glucose transport defect, blood-brain barrier
  • Glucose transporter protein syndrome
  • Glucose transporter type 1 deficiency syndrome

1 GLUT1 deficiency syndrome. National Institutes of Health: Genetics Home Reference Website. https://ghr.nlm.nih.gov/condition/glut1-deficiency-syndrome#synonyms. Published March 2014. Updated March 19, 2019. Accessed March 29, 2019.

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